منابع مشابه
Mitotic partitioning of endosomes and lysosomes
BACKGROUND Some of the mechanisms underlying cell division and partitioning of the cellular components into the daughter cells are well known. Within the endomembrane system, there is a general cessation of membrane traffic, including endocytosis and endosome fusion, at the onset of mitosis. However, the fate of endosomes and lysosomes during mitosis has been less well studied. RESULTS Using ...
متن کاملDelivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
After endocytosis, lysosomally targeted ligands pass through a series of endosomal compartments. The endocytic apparatus that accomplishes this passage may be considered to take one of two forms: (a) a system in which lysosomally targeted ligands pass through preexisting, long-lived early sorting endosomes and are then selectively transported to long-lived late endosomes in carrier vesicles, or...
متن کاملRecycling endosomes
Heparin sustains the brain myloid plaque formation can be inhibited by an unlikely culprit, according to work by Scholefield et al. on page 97. The group finds that heparan sulfate (HS)—normally a part of the cell surface and extracellular matrix—functions in cells to slow the production of the plaque components of Alzheimer's disease. Amyloid plaques are aggregates of the amyloid -peptide (A ...
متن کاملWhy endosomes recycle GPCRs
Bowman et al. provide a novel explanation for why activated G protein–coupled receptors (GPCRs) migrate from the cell surface to the endosomes (1). The study indicates that GPCRs that have moved to certain locations on endosomes activate specifi c genes—and thus presumably induce different cellular responses. GPCRs help us perceive our surroundings, control our blood pressure, mobilize our immu...
متن کاملEndosomes make tracks
arly endosomes may help to create their own short-range tracks, according to a report from Stéphane Gasman, Yannis Kalaidzidis, and Marino Zerial (Max Planck Institute, Dresden, Germany). The results also suggest parallels between membrane trafficking, signaling, and regulation of the cytoskeleton. Trafficking of early endosomes requires the small GTPase RhoD. Zerial’s group identified the firs...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1756rr2